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A Lethal Dose

Posted by on Jan 28, 2015 in Blog Posts | 0 comments

Scientists who work with toxic substances, as well as people who keep (or whose family members keep) venomous animals are (or should be) familiar with the LD50 designation, originally called the DL50 system for dosis letalis 50%. The LD50 of a toxin is the dose at which 50% of the test subjects that ingest the substance die. Invented by J.W. Trevan, a British pharmacologist who published his research on lethal doses in 1927, the LD50 system expresses toxicity in terms of mass of the toxin per mass of the test subject, usually in milligrams (mg) of the substance per kilogram (kg) of body mass. Because the LD50 is a median, some study subjects will survive a higher dose, while other subjects will be killed by doses lower than the median. The LD50 can also be influenced by the species being studied...

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A Lethal Dose

Posted by on Jan 28, 2015 in Blog Posts | 0 comments

Scientists who work with toxic substances, as well as people who keep (or whose family members keep) venomous animals are (or should be) familiar with the LD50 designation, originally called the DL50 system for dosis letalis 50%. The LD50 of a toxin is the dose at which 50% of the test subjects that ingest the substance die. Invented by J.W. Trevan, a British pharmacologist who published his research on lethal doses in 1927, the LD50 system expresses toxicity in terms of mass of the toxin per mass of the test subject, usually in milligrams (mg) of the substance per kilogram (kg) of body mass. Because the LD50 is a median, some study subjects will survive a higher dose, while other subjects will be killed by doses lower than the median. The LD50 can also be influenced by the species being studied...

Read More

A Lethal Dose

Posted by on Jan 28, 2015 in Blog Posts | 0 comments

Scientists who work with toxic substances, as well as people who keep (or whose family members keep) venomous animals are (or should be) familiar with the LD50 designation, originally called the DL50 system for dosis letalis 50%. The LD50 of a toxin is the dose at which 50% of the test subjects that ingest the substance die. Invented by J.W. Trevan, a British pharmacologist who published his research on lethal doses in 1927, the LD50 system expresses toxicity in terms of mass of the toxin per mass of the test subject, usually in milligrams (mg) of the substance per kilogram (kg) of body mass. Because the LD50 is a median, some study subjects will survive a higher dose, while other subjects will be killed by doses lower than the median. The LD50 can also be influenced by the species being studied...

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Munchausen syndrome by proxy — factitious or fiction?

Posted by on Jan 27, 2015 in Blog Posts | 0 comments

Jury selection began yesterday in the Westchester County, New York, case of Lacey Spears, 27, a mother accused of killing her child, Garnett, by dosing the 5-year-old boy with salt. As the child’s condition deteriorated, requiring multiple hospitalizations, Spears posted about the boy’s medical status on social media, garnering much attention and sympathy. Spears is facing charges of second-degree murder and manslaughter in the death of her son. It’s alleged that, even as Garnett suffered repeated hospitalizations, Spears continued to dose him with salt through a feeding tube. A feeding tube bag, seized from Spears’ home after the boy’s death, allegedly contained a high concentration of sodium. Spears’ attorneys asked the court to restrict mention during the trial of Munchausen Syndrome by Proxy (MSP), a syndrome that might explain some of the mother’s behavior. According to the Merck Manual, a respected...

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Munchausen syndrome by proxy — factitious or fiction?

Posted by on Jan 27, 2015 in Blog Posts | 0 comments

Jury selection began yesterday in the Westchester County, New York, case of Lacey Spears, 27, a mother accused of killing her child, Garnett, by dosing the 5-year-old boy with salt. As the child’s condition deteriorated, requiring multiple hospitalizations, Spears posted about the boy’s medical status on social media, garnering much attention and sympathy. Spears is facing charges of second-degree murder and manslaughter in the death of her son. It’s alleged that, even as Garnett suffered repeated hospitalizations, Spears continued to dose him with salt through a feeding tube. A feeding tube bag, seized from Spears’ home after the boy’s death, allegedly contained a high concentration of sodium. Spears’ attorneys asked the court to restrict mention during the trial of Munchausen Syndrome by Proxy (MSP), a syndrome that might explain some of the mother’s behavior. According to the Merck Manual, a respected...

Read More